3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid

Base Information

• Chemical Name: 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid
• CAS No.: 1334546-83-6
• Molecular Formula: C₁₃H₇Cl₂F₃N₂O₂
• Molecular Weight: 351.112
• Mol file: 1334546-83-6.mol

Synonyms:3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid

Chemical Property of 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid

There total 8 articles about 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid methyl ester (1334547-23-7) → 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid (1334546-83-6)

Guidance literature:

3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid methyl ester; With methanol; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In water; pH=4;

Reference yield:

3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (866775-17-9) → 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid (1334546-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C

2.1: potassium phosphate / Fibrecat_.(R). 1034A / toluene; water / 3 h / 110 °C

3.1: sodium hydroxide; methanol / 1,4-dioxane / 20 °C

3.2: pH 4

With methanol; potassium phosphate; sulfuric acid; bromine; acetic acid; sodium hydroxide; Fibrecat 1034A; In 1,4-dioxane; water; toluene;

Reference yield:

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (866775-18-0) → 3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid (1334546-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium phosphate / Fibrecat_.(R). 1034A / toluene; water / 3 h / 110 °C

2.1: sodium hydroxide; methanol / 1,4-dioxane / 20 °C

2.2: pH 4

With methanol; potassium phosphate; sodium hydroxide; Fibrecat 1034A; In 1,4-dioxane; water; toluene;

upstream raw materials:

3-nitro-5-trifluoromethylpyridin-2-ol

3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile

3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester