N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide
CAS No.:1217334-68-3
Molecular Formula:C₂₁H₂₁FN₄O₄S
Molecular Weight:444.487
Hs Code.:

Synonyms:N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

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Chemical Property of N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

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Technology Process of N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

There total 4 articles about N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1217339-08-6
2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1217334-68-3
N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

: 1217339-24-6
N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)methanesulfonamide

Guidance literature:: 2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxamide; N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 85 ℃; for 1h;

With acetic acid; hydrazine; In 1,4-dioxane; at 85 ℃;

Reference yield:

: 691857-10-0
2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

: 1217334-68-3
N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

: 1217339-24-6
N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia; HATU / N,N-dimethyl-formamide; methanol / 1 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 1 h / 85 °C

2.2: 85 °C

With ammonia; HATU; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1217340-86-7
methyl 2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxylate

: 1217334-68-3
N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)-N-methylmethanesulfonamide

: 1217339-24-6
N-(2-(4-fluorophenyl)-5-isopropoxy-3-(1H-1,2,4-triazol-5-yl)benzofuran-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 60 - 67 °C

2.1: ammonia; HATU / N,N-dimethyl-formamide; methanol / 1 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 1 h / 85 °C

3.2: 85 °C

With ammonia; water; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;