4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

Base Information

Chemical Name:4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone
CAS No.:1326283-32-2
Molecular Formula:C₁₃H₁₄BrN₃O
Molecular Weight:308.178
Hs Code.:

Synonyms:4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

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Chemical Property of 4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

Chemical Property:

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Technology Process of 4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

There total 7 articles about 4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3685-26-5,17419-81-7,3685-22-1
cis-4-hydroxycyclohexanecarboxylic acid

: 1326283-32-2
4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / pH 8

2.1: dmap; pyridine / 1 h / 0 - 20 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / 70 °C

3.2: 0.5 h / 0 - 20 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1 h / 95 °C / Inert atmosphere

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: potassium hydroxide; water / acetonitrile / 100 °C

6.2: 20 °C

7.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetone / 20 °C

With pyridine; dmap; N-Bromosuccinimide; tetrapropylammonium perruthennate; water; potassium carbonate; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1326283-30-0
(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

: 1326283-32-2
4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In acetone; at 20 ℃;

Reference yield:

: 1326283-22-0
(cis)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

: 1326283-32-2
4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; pyridine / 1 h / 0 - 20 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / 70 °C

2.2: 0.5 h / 0 - 20 °C

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1 h / 95 °C / Inert atmosphere

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: potassium hydroxide; water / acetonitrile / 100 °C

5.2: 20 °C

6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetone / 20 °C

With pyridine; dmap; N-Bromosuccinimide; tetrapropylammonium perruthennate; water; potassium carbonate; 4-methylmorpholine N-oxide; potassium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; acetonitrile;