(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

Base Information

Chemical Name:(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol
CAS No.:1326283-30-0
Molecular Formula:C₁₃H₁₆BrN₃O
Molecular Weight:310.194
Hs Code.:

Synonyms:(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

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Chemical Property of (cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

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Technology Process of (cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

There total 6 articles about (cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3685-26-5,17419-81-7,3685-22-1
cis-4-hydroxycyclohexanecarboxylic acid

: 1326283-30-0
(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / pH 8

2.1: dmap; pyridine / 1 h / 0 - 20 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / 70 °C

3.2: 0.5 h / 0 - 20 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1 h / 95 °C / Inert atmosphere

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: potassium hydroxide; water / acetonitrile / 100 °C

6.2: 20 °C

With pyridine; dmap; N-Bromosuccinimide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1326283-27-5
(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl acetate

: 1326283-30-0
(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

Guidance literature:: (cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl acetate; With water; potassium hydroxide; In acetonitrile; at 100 ℃;

With hydrogenchloride; In water; acetonitrile; at 20 ℃;

Reference yield:

: 1326283-24-2
(cis)-4-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclohexyl acetate

: 1326283-30-0
(cis)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1 h / 95 °C / Inert atmosphere

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: potassium hydroxide; water / acetonitrile / 100 °C

3.2: 20 °C

With N-Bromosuccinimide; water; potassium carbonate; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;