tert-butyl (2-(2-aminophenoxy)ethyl)carbamate

Base Information

• Chemical Name: tert-butyl (2-(2-aminophenoxy)ethyl)carbamate
• CAS No.: 263410-16-8
• Molecular Formula: C₁₃H₂₀N₂O₃
• Molecular Weight: 252.313
• Mol file: 263410-16-8.mol

Synonyms:tert-butyl (2-(2-aminophenoxy)ethyl)carbamate

Chemical Property of tert-butyl (2-(2-aminophenoxy)ethyl)carbamate

Chemical Property:

• Boiling Point: 411.2±25.0 °C(Predicted)
• PKA: 12.11±0.46(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(2-(2-aminophenoxy)ethyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2-(2-aminophenoxy)ethyl)carbamate

There total 2 articles about tert-butyl (2-(2-aminophenoxy)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (2-(2-nitrophenoxy)ethyl)carbamate (263410-15-7) → tert-butyl (2-(2-aminophenoxy)ethyl)carbamate (263410-16-8)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; for 10h; under 836.056 Torr;

DOI:10.1016/j.bmc.2014.05.061

Reference yield:

2-(tert-butoxycarbonylamino)ethyl bromide (39684-80-5) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → tert-butyl (2-(2-aminophenoxy)ethyl)carbamate (263410-16-8)

Guidance literature:

2-(tert-butoxycarbonylamino)ethyl bromide; 2-hydroxynitrobenzene; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

With palladium on activated charcoal; hydrogen; In ethanol;

Reference yield: 71.0%

bis(trichloromethyl) carbonate (32315-10-9) + (S)-2-[3-((S)-5-amino-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester (1025796-31-9) + tert-butyl (2-(2-aminophenoxy)ethyl)carbamate (263410-16-8) → (S)-di-tert-butyl 2-(3-((S)-1-(tert-butoxy)-6-(3-(2-(2-((tert-butoxycarbonyl)amino)ethoxy)phenyl)ureido)-1-oxohexan-2-yl)ureido)pentane-1,5-dioate

Guidance literature:

bis(trichloromethyl) carbonate; tert-butyl (2-(2-aminophenoxy)ethyl)carbamate; In dichloromethane; at 0 - 20 ℃; for 2h;

(S)-2-[3-((S)-5-amino-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester; In dichloromethane; for 12h;

DOI:10.1016/j.bmc.2014.05.061

upstream raw materials:

2-(tert-butoxycarbonylamino)ethyl bromide

2-hydroxynitrobenzene

tert-butyl (2-(2-nitrophenoxy)ethyl)carbamate

Downstream raw materials:

C₁₉H₂₇N₃O₆

C₁₈H₂₄N₆O₄S

C₂₆H₂₈N₆O₄S

C₂₁H₂₀N₆O₂S

Refernces

• 1、 -. "PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX". Page/Page column 40. . Retrieved 2013/04/25.