benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride

Base Information

• Chemical Name: benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride
• CAS No.: 1402232-57-8
• Molecular Formula: C₁₆H₂₂N₂O₃*ClH
• Molecular Weight: 326.823
• Mol file: 1402232-57-8.mol

Synonyms:benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride

Chemical Property of benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride

There total 3 articles about benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate (1097920-69-8) → benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride (1402232-57-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester (930785-40-3) → benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride (1402232-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride (1402232-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

upstream raw materials:

4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester

benzyl chloroformate