5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Base Information

Chemical Name:5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine
CAS No.:1084952-83-9
Molecular Formula:C₂₃H₂₁F₃N₆O₂
Molecular Weight:470.454
Hs Code.:

Synonyms:5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

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Chemical Property of 5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

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Technology Process of 5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

There total 8 articles about 5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1084953-21-8
(3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)carbamic acid benzyl ester

: 1084952-83-9
5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; at 20 ℃; for 48h; under 3750.38 Torr;

Reference yield:

: 2754-18-9
3,3-bis(hydroxymethyl)oxetane

: 1084952-83-9
5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 10 - 20 °C

3: ammonia / methanol / 144 h

4: sodium carbonate / dichloromethane; water / 1 h / 20 °C

5: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 95 °C

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 6 h / Heating / reflux

7: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol; N,N-dimethyl-formamide / 48 h / 20 °C / 3750.38 Torr

With di-isopropyl azodicarboxylate; ammonia; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 115-77-5
Pentaerythritol

: 1084952-83-9
5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide; Diethyl carbonate / ethanol / 4 h / Heating / reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 10 - 20 °C

4: ammonia / methanol / 144 h

5: sodium carbonate / dichloromethane; water / 1 h / 20 °C

6: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 95 °C

7: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 6 h / Heating / reflux

8: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol; N,N-dimethyl-formamide / 48 h / 20 °C / 3750.38 Torr

With potassium hydroxide; di-isopropyl azodicarboxylate; ammonia; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; Diethyl carbonate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;