cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

Base Information

Chemical Name:cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide
CAS No.:1084952-85-1
Molecular Formula:C₂₇H₂₅F₃N₆O₃
Molecular Weight:538.529
Hs Code.:

cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

Synonyms:cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

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Chemical Property of cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

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Technology Process of cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

There total 9 articles about cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1084952-83-9
5-(6-(4-(3-aminomethyloxetan-3-ylmethoxy)phenyl)imidazo[1,2-b]pyridazin-3-yl)-3-trifluoromethylpyridin-2-ylamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1084952-85-1
cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 2754-18-9
3,3-bis(hydroxymethyl)oxetane

: 1084952-85-1
cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 10 - 20 °C

3: ammonia / methanol / 144 h

4: sodium carbonate / dichloromethane; water / 1 h / 20 °C

5: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 95 °C

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 6 h / Heating / reflux

7: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol; N,N-dimethyl-formamide / 48 h / 20 °C / 3750.38 Torr

8: potassium carbonate / acetonitrile / 4 h / 20 °C

With di-isopropyl azodicarboxylate; ammonia; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 115-77-5
Pentaerythritol

: 1084952-85-1
cyclopropanecarboxylic acid (3-(4-(3-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)phenoxymethyl)oxetan-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium hydroxide; Diethyl carbonate / ethanol / 4 h / Heating / reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 10 - 20 °C

4: ammonia / methanol / 144 h

5: sodium carbonate / dichloromethane; water / 1 h / 20 °C

6: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 95 °C

7: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 6 h / Heating / reflux

8: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol; N,N-dimethyl-formamide / 48 h / 20 °C / 3750.38 Torr

9: potassium carbonate / acetonitrile / 4 h / 20 °C

With potassium hydroxide; di-isopropyl azodicarboxylate; ammonia; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; Diethyl carbonate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;