N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

Base Information

Chemical Name:N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea
CAS No.:853297-19-5
Molecular Formula:C₂₄H₂₆F₃N₇O₂
Molecular Weight:501.511
Hs Code.:

Synonyms:N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

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Chemical Property of N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

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Technology Process of N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

There total 11 articles about N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-benzoyloxycarbonylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-urea

: 853297-19-5
N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 853297-19-5
N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water; acetone / 1 h / 60 - 65 °C

2: hydrogen / nickel / methanol / 72 h / 40 °C

3: dichloromethane; toluene / 0.5 h / -20 °C

4: tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

5: ethanol / 2 h / 0 °C

6: hydrogen / palladium 10% on activated carbon / methanol

With sodium hydroxide; hydrogen; palladium 10% on activated carbon; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; toluene;

Reference yield:

: N-(3-trifluoromethyl-4-methylphenyl)-2,2,2-trifluoroacetamide

: 853297-19-5
N-[4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-H-piperazin-1-ylmethyl)-5-trifluoromethyl-phenyl]-urea

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetic acid butyl ester / 6.5 h / 60 - 75 °C

2: ethanol / 0.58 h

3: water; potassium carbonate / methanol / 1 h

4: tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

5: ethanol / 2 h / 0 °C

6: hydrogen / palladium 10% on activated carbon / methanol

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; acetic acid butyl ester;