4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

Base Information

Chemical Name:4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide
CAS No.:1314217-78-1
Molecular Formula:C₁₇H₁₅BrF₃NO₃
Molecular Weight:418.21
Hs Code.:

Synonyms:4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

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Chemical Property of 4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

Chemical Property:

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Technology Process of 4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

There total 4 articles about 4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

: 1314217-74-7
5-bromo-7-methyl-2-benzofuran-1(3H)-one

: 93919-56-3
4-(trifluoromethoxy)benzyl amine

: 1314217-78-1
4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

Guidance literature:: With trimethylaluminum; In 2-methyltetrahydrofuran; at 40 ℃; Inert atmosphere;

Reference yield:

: 74346-19-3
4-bromo-2,6-dimethylbenzoic acid

: 1314217-78-1
4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / chlorobenzene / 70 °C

2: sodium tetrahydroborate / N,N-dimethyl acetamide

3: trimethylaluminum / 2-methyltetrahydrofuran / 40 °C / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; trimethylaluminum; dibenzoyl peroxide; In 2-methyltetrahydrofuran; N,N-dimethyl acetamide; chlorobenzene;

Reference yield:

: 206559-43-5,260355-37-1
5-bromo-2-iodo-1,3-dimethyl-benzene

: 1314217-78-1
4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: isopropylmagnesium chloride / tert-butyl methyl ether / 0 °C

2: dibenzoyl peroxide; N-Bromosuccinimide / chlorobenzene / 70 °C

3: sodium tetrahydroborate / N,N-dimethyl acetamide

4: trimethylaluminum / 2-methyltetrahydrofuran / 40 °C / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; trimethylaluminum; isopropylmagnesium chloride; dibenzoyl peroxide; In 2-methyltetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl acetamide; chlorobenzene; 1: Grignard Reaction;