7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

Base Information

Chemical Name:7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS No.:877149-74-1
Molecular Formula:C₁₈H₁₄F₃NO₄
Molecular Weight:365.309
Hs Code.:

Synonyms:7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

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Chemical Property of 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

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Technology Process of 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

There total 13 articles about 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1314217-86-1
ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate

: 877149-74-1
7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

Guidance literature:: ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate; With water; potassium hydroxide; In isopropyl alcohol; Heating;

With hydrogenchloride; In water;

Reference yield: 85.0%

: 877149-62-7
7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile

: 877149-74-1
7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

Guidance literature:: 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile; With water; potassium hydroxide; In methanol; Heating;

With hydrogenchloride; In water;

Reference yield:

: 74346-19-3
4-bromo-2,6-dimethylbenzoic acid

: 877149-74-1
7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / chlorobenzene / 70 °C

2: sodium tetrahydroborate / N,N-dimethyl acetamide

3: trimethylaluminum / 2-methyltetrahydrofuran / 40 °C / Inert atmosphere

4: triethylamine / 2-methyltetrahydrofuran / 5 °C

5: sodium tert-pentoxide / 2-methyltetrahydrofuran / 5 °C

6: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 90 °C / Inert atmosphere

7: potassium hydroxide; water / methanol / Heating

With sodium tetrahydroborate; N-Bromosuccinimide; water; trimethylaluminum; sodium tert-pentoxide; triethylamine; potassium hydroxide; dibenzoyl peroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 2-methyltetrahydrofuran; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; chlorobenzene;