N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide

Base Information

• Chemical Name: N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide
• CAS No.: 41377-69-9
• Molecular Formula: C₁₃H₁₀N₄O₄
• Molecular Weight: 286.247
• Mol file: 41377-69-9.mol

Synonyms:N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide

Chemical Property of N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide

There total 5 articles about N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Nicotinic acid hydrazide (553-53-7) + 5-Nitrosalicylaldehyde (97-51-8) → N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide (41377-69-9)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmc.2015.04.040

Reference yield:

nicotinic acid (59-67-6) → N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide (41377-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Amberlyst-15

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: ethanol / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2015.04.040

Reference yield:

3-pyridinecarboxylic acid ethyl ester (614-18-6) → N′-(2-hydroxy-5-nitrophenyl-methylidene)-3-pyridincarbohydrazide (41377-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / Reflux

2: ethanol / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2015.04.040

upstream raw materials:

Nicotinic acid hydrazide

5-Nitrosalicylaldehyde

nicotinic acid

3-pyridinecarboxylic acid ethyl ester