(1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

Base Information

Chemical Name:(1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane
CAS No.:449174-21-4
Molecular Formula:C₂₇H₄₂O₄Si
Molecular Weight:458.714
Hs Code.:

Synonyms:(1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

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Chemical Property of (1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

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Technology Process of (1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

There total 3 articles about (1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: Chloro-[(R)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropyl-silane

: 449174-21-4
(1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ol026046+

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 449174-21-4
(1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / triflic acid / diethyl ether / 1 h / 20 °C

2: 96 percent / i-PrMgCl / tetrahydrofuran / 0.75 h / -20 - -15 °C

3: 91 percent / tetrahydrofuran; diethyl ether / 1 h / -20 °C

4: 89 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 1 h / 0 °C

5: imidazole / dimethylformamide / 1 h

6: 1.39 g / imidazole / CH₂Cl₂ / 16 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol026046+

Reference yield:

: 213385-33-2
(R)-1-((4-methoxybenzyl)oxy)-2-methylpentan-3-one

: 449174-21-4
(1RS,2R)-benzyloxy-[1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-diisopropylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 1 h / 0 °C

2: imidazole / dimethylformamide / 1 h

3: 1.39 g / imidazole / CH₂Cl₂ / 16 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol026046+