(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

Base Information

Chemical Name:(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide
CAS No.:1612163-45-7
Molecular Formula:C₂₃H₃₁BrN₂O₃
Molecular Weight:463.415
Hs Code.:

Synonyms:(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

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Chemical Property of (S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

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Technology Process of (S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

There total 4 articles about (S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1612163-84-4
(R,Z)-N-(1-(benzyloxy)-3,3-dimethylbutan-2-yl)-1-(4-bromophenyl)methanimine oxide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1612163-45-7
(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

: 1612163-51-5
(R)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

Guidance literature:: With lithium 2,2,6,6-tetramethylpiperidide; In toluene; at 0 ℃; for 0.333333h; diastereoselective reaction;
DOI:10.1021/jo500848a

Reference yield:

: 1612163-80-0
(R)-O-benzoyl-N-(1-(benzyloxy)-3,3-dimethylbutan-2-yl)-hydroxylamine

: 1612163-45-7
(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

: 1612163-51-5
(R)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol / 18 h / 20 °C

2: magnesium sulfate / dichloromethane / 18 h / 20 °C

3: lithium 2,2,6,6-tetramethylpiperidide / toluene / 0.33 h / 0 °C

With ammonium hydroxide; lithium 2,2,6,6-tetramethylpiperidide; magnesium sulfate; In methanol; dichloromethane; toluene;
DOI:10.1021/jo500848a

Reference yield:

: 1612163-82-2
(R)-N-(1-(benzyloxy)-3,3-dimethylbutan-2-yl)hydroxylamine

: 1612163-45-7
(S)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

: 1612163-51-5
(R)-2-(((R)-1-(benzyloxy)-3,3-dimethylbutan-2-yl)(hydroxy)-amino)-2-(4-bromo-phenyl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / dichloromethane / 18 h / 20 °C

2: lithium 2,2,6,6-tetramethylpiperidide / toluene / 0.33 h / 0 °C

With lithium 2,2,6,6-tetramethylpiperidide; magnesium sulfate; In dichloromethane; toluene;
DOI:10.1021/jo500848a