2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

Base Information

Chemical Name:2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone
CAS No.:329075-87-8
Molecular Formula:C₂₂H₂₁FN₂O₄S
Molecular Weight:428.484
Hs Code.:

Synonyms:2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

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Chemical Property of 2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

Chemical Property:

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Technology Process of 2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

There total 11 articles about 2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 822-87-7
2-Chlorocyclohexanone

: 329076-65-5
4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-3-hydroxypyrazole

: 329075-87-8
2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 50 ℃;

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 329075-87-8
2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

3: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

4: K₂CO₃ / dimethylformamide / 50 °C

With peracetic acid; potassium carbonate; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo049264k

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 329075-87-8
2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂SO₄ / 8 h / Heating

2: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

3: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

4: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

5: K₂CO₃ / dimethylformamide / 50 °C

With peracetic acid; sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo049264k