hetacillin methyl ester

Base Information

Chemical Name:hetacillin methyl ester
CAS No.:4052-65-7
Molecular Formula:C₂₀H₂₅N₃O₄S
Molecular Weight:403.502
Hs Code.:

Synonyms:hetacillin methyl ester

Suppliers and Price of hetacillin methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of hetacillin methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of hetacillin methyl ester

There total 1 articles about hetacillin methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 3511-16-8
hetacillin

: 4052-65-7
hetacillin methyl ester

Guidance literature:: In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1002/hlca.19800630119

Reference yield: 79.0%

: 4052-65-7
hetacillin methyl ester

: 73932-87-3
hetacillin methyl ester S-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1002/hlca.19800630119

Reference yield:

: 4052-65-7
hetacillin methyl ester

: 73933-06-9
t-butyl 7(R)-(2,2-dimethyl-3-t-butoxycarbonyl-4(R)-phenyl-imidazolid-5-on-1-yl)-3-methyl-2-oxo-(6R)-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 15 steps

1: 79 percent / 90percent m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 56 percent / benzene / 90 h / Heating

3: 97 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 89 percent / i-Pr₂NEt / dioxane / 72 h / 50 °C

5: 1.) PH₃P / 1.) H₂O, CH₂Cl₂, 0 to 5 deg C, 88 h, 2.) pyridine, RT; 4.5 h

6: 85 percent / AcOH / tetrahydrofuran; H₂O / 21 h / Ambient temperature

7: 7.93 g / O₃ / methanol / 2.17 h / -40 °C

8: methanol; tetrahydrofuran; H₂O / Ambient temperature

9: Et₃N / dimethylformamide / 2 h / Ambient temperature

10: 69 percent / 1N HCl / acetonitrile; H₂O / 17 h / Ambient temperature

11: 573 mg / molecular sieves 4A / dimethylformamide; toluene / 3 h / Ambient temperature

12: 495 mg / SOCl₂, polymeric base / dioxane / 3 h / Ambient temperature

13: 78 percent / polymeric base / dioxane / 38 h / 50 °C

14: 1.) O₃/O₂, 2.) Me₂S / 1.) CH₂Cl₂, TFA, -25 deg C, 42 min, 2.) CH₂Cl₂, TFA, -25 deg C, 17 h

15: 290 mg / toluene / 9 h / 60 °C

With hydrogenchloride; thionyl chloride; dimethylsulfide; 4 A molecular sieve; polymeric base; oxygen; ozone; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1002/hlca.19800630119