methylacryloylthio azetidinone

Base Information

Chemical Name:methylacryloylthio azetidinone
CAS No.:73933-00-3
Molecular Formula:C₂₃H₂₉N₃O₅S
Molecular Weight:459.566
Hs Code.:

Synonyms:methylacryloylthio azetidinone

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Chemical Property of methylacryloylthio azetidinone

Chemical Property:

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Technology Process of methylacryloylthio azetidinone

There total 12 articles about methylacryloylthio azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 73932-99-7
N-(dimethyl-t-butylsilyl) methylacryloylthio azetidinone

: 73933-00-3
methylacryloylthio azetidinone

Guidance literature:: With hydrogenchloride; In water; acetonitrile; for 17h; Ambient temperature;
DOI:10.1002/hlca.19800630119

Reference yield:

: 4052-65-7
hetacillin methyl ester

: 73933-00-3
methylacryloylthio azetidinone

Guidance literature:: Multi-step reaction with 10 steps

1: 79 percent / 90percent m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 56 percent / benzene / 90 h / Heating

3: 97 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 89 percent / i-Pr₂NEt / dioxane / 72 h / 50 °C

5: 1.) PH₃P / 1.) H₂O, CH₂Cl₂, 0 to 5 deg C, 88 h, 2.) pyridine, RT; 4.5 h

6: 85 percent / AcOH / tetrahydrofuran; H₂O / 21 h / Ambient temperature

7: 7.93 g / O₃ / methanol / 2.17 h / -40 °C

8: methanol; tetrahydrofuran; H₂O / Ambient temperature

9: Et₃N / dimethylformamide / 2 h / Ambient temperature

10: 69 percent / 1N HCl / acetonitrile; H₂O / 17 h / Ambient temperature

With hydrogenchloride; ozone; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/hlca.19800630119

Reference yield:

: 3511-16-8
hetacillin

: 73933-00-3
methylacryloylthio azetidinone

Guidance literature:: Multi-step reaction with 11 steps

1: 88 percent / CH₂Cl₂; diethyl ether / 0.5 h / 0 °C

2: 79 percent / 90percent m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 56 percent / benzene / 90 h / Heating

4: 97 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

5: 89 percent / i-Pr₂NEt / dioxane / 72 h / 50 °C

6: 1.) PH₃P / 1.) H₂O, CH₂Cl₂, 0 to 5 deg C, 88 h, 2.) pyridine, RT; 4.5 h

7: 85 percent / AcOH / tetrahydrofuran; H₂O / 21 h / Ambient temperature

8: 7.93 g / O₃ / methanol / 2.17 h / -40 °C

9: methanol; tetrahydrofuran; H₂O / Ambient temperature

10: Et₃N / dimethylformamide / 2 h / Ambient temperature

11: 69 percent / 1N HCl / acetonitrile; H₂O / 17 h / Ambient temperature

With hydrogenchloride; ozone; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/hlca.19800630119