BIS THF Nitro Derivative 1

Base Information

Chemical Name:BIS THF Nitro Derivative 1
CAS No.:288296-64-0
Molecular Formula:C₁₃H₁₃NO₇
Molecular Weight:295.249
Hs Code.:
Mol file:288296-64-0.mol

Synonyms:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-4-nitrophenyl carbonate

Suppliers and Price of BIS THF Nitro Derivative 1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl4-NitrophenylEsterCarbonicAcid
50mg
$ 1260.00

Total 6 raw suppliers

Chemical Property of BIS THF Nitro Derivative 1

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl4-NitrophenylEsterCarbonicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl ester carbonic acid is an impurity of bis-THF-derived compounds (such as [1-benzyl-2-hydroxy-3-(arylsulfonamido)propyl]carbamates) that act as HIV-aspartyl protease inhibitors.

Technology Process of BIS THF Nitro Derivative 1

There total 10 articles about BIS THF Nitro Derivative 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 156928-10-8
(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan

: 288296-64-0,252873-01-1,252873-35-1
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-4-nitrophenyl carbonate

Guidance literature:: With 4-methyl-morpholine;
DOI:10.1016/S0960-894X(96)00528-8

Reference yield:

: 1378929-91-9
ethyl 2-(2-ethoxy-tetrahydrofuran-3-yl)-2-oxoacetate

: 288296-64-0,252873-01-1,252873-35-1
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 15 - 55 °C / Inert atmosphere

1.2: 20 - 30 °C

2.1: dmap; triethylamine / dichloromethane / 0 - 35 °C

3.1: sodium dihydrogenphosphate; sodium hydrogencarbonate / water / 56 h / 38 - 45 °C / pH 6 - 6.5

4.1: potassium carbonate / methanol / 25 - 35 °C

5.1: triethylamine / dichloromethane / 20 - 30 °C

With dmap; sodium tetrahydroborate; sodium dihydrogenphosphate; sodium hydrogencarbonate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 96406-00-7
(4,5-Dihydro-3-furanyl)glyoxylsaeure-ethylester

: 288296-64-0,252873-01-1,252873-35-1
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dichloromethane / 5 - 30 °C

2.1: sodium sulfite / water / 25 - 35 °C

3.1: sodium tetrahydroborate / ethanol / 15 - 55 °C / Inert atmosphere

3.2: 20 - 30 °C

4.1: dmap; triethylamine / dichloromethane / 0 - 35 °C

5.1: sodium dihydrogenphosphate; sodium hydrogencarbonate / water / 56 h / 38 - 45 °C / pH 6 - 6.5

6.1: potassium carbonate / methanol / 25 - 35 °C

7.1: triethylamine / dichloromethane / 20 - 30 °C

With dmap; sodium tetrahydroborate; sodium dihydrogenphosphate; N-Bromosuccinimide; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium sulfite; In methanol; ethanol; dichloromethane; water;