[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

Base Information

Chemical Name:[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate
CAS No.:1403935-00-1
Molecular Formula:C₂₅H₂₅NO₉
Molecular Weight:483.475
Hs Code.:

[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

Synonyms:[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

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Chemical Property of [(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

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Technology Process of [(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

There total 6 articles about [(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1403934-99-5
((3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-6-hydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl)methyl benzoate

: 1403935-00-1
[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1139/v2012-073

Reference yield:

: 1329120-35-5
N-[(3aS,4R,5R,6S,7S,7aS)-7-{[tert-butyl(dimethyl)silyl]oxy}-6,6'-bis(hydroxymethyl)-7'-methoxy-2,2-dimethyl-3,4,5,6,7,7a-hexahydro-5,5'-bi-1,3-benzodioxol-4-yl]-4-methylbenzenesulfonamide

: 1403935-00-1
[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: manganese(IV) oxide / dichloromethane / 48 h / Inert atmosphere

2: pyridine / dichloromethane / 24 h / Inert atmosphere

3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / Inert atmosphere; Molecular sieve

4: naphthalene; sodium / 1,2-dimethoxyethane / -50 °C / Inert atmosphere

5: triethylamine; dmap / dichloromethane / 0 °C / Inert atmosphere

6: lithium chloride / N,N-dimethyl-formamide / 3.5 h / 120 °C / Inert atmosphere

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere

With pyridine; dmap; manganese(IV) oxide; tetrapropylammonium perruthennate; naphthalene; tetrabutyl ammonium fluoride; sodium; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v2012-073

Reference yield:

: 1329120-38-8
{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

: 1403935-00-1
[(3aS,3bR,10bR,11S,12S,12aR)-6,12-dihydroxy-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl]methyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: naphthalene; sodium / 1,2-dimethoxyethane / -50 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 0 °C / Inert atmosphere

3: lithium chloride / N,N-dimethyl-formamide / 3.5 h / 120 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere

With dmap; naphthalene; tetrabutyl ammonium fluoride; sodium; triethylamine; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v2012-073