{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

Base Information

Chemical Name:{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate
CAS No.:1329120-37-7
Molecular Formula:C₃₄H₄₇NO₁₁SSi
Molecular Weight:705.899
Hs Code.:

{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

Synonyms:{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

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Chemical Property of {(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

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Technology Process of {(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

There total 8 articles about {(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1329120-36-6
(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-11-(hydroxymethyl)-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-5-ol

: 108-24-7
acetic anhydride

: 1329120-37-7
{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

Guidance literature:: With pyridine; In dichloromethane; for 24h;
DOI:10.1016/j.bmcl.2011.06.068

Reference yield:

: 1329120-31-1
C₂₆H₂₇NO₈S

: 1329120-37-7
{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / methanol

2: triethylamine / dichloromethane / 0 °C

3: silica gel / quinoline / 120 °C

4: ozone; solvent red 19 / methanol / -80 °C

5: sodium tetrahydroborate / -80 - 20 °C

6: manganese(IV) oxide / dichloromethane / 48 h

7: pyridine / dichloromethane / 24 h

With pyridine; manganese(IV) oxide; sodium tetrahydroborate; hydrogen; silica gel; ozone; triethylamine; solvent red 19; In quinoline; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.068

Reference yield:

: 1329120-32-2
C₂₆H₂₉NO₈S

: 1329120-37-7
{(3aS,3bR,10bR,11S,12S,12aS)-12-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-6-methoxy-2,2-dimethyl-4-[(4-methylphenyl)sulfonyl]-3,3b,4,5,10b,11,12,12aoctahydrobis[1,3]dioxolo[4,5-c:4',5'-j]phenanthridin-11-yl}methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 0 °C

2: silica gel / quinoline / 120 °C

3: ozone; solvent red 19 / methanol / -80 °C

4: sodium tetrahydroborate / -80 - 20 °C

5: manganese(IV) oxide / dichloromethane / 48 h

6: pyridine / dichloromethane / 24 h

With pyridine; manganese(IV) oxide; sodium tetrahydroborate; silica gel; ozone; triethylamine; solvent red 19; In quinoline; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.068