N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

Base Information

Chemical Name:N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide
CAS No.:1186643-38-8
Molecular Formula:C₂₉H₃₄ClN₅O₆S
Molecular Weight:616.138
Hs Code.:

N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

Synonyms:N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

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Chemical Property of N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

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Technology Process of N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

There total 7 articles about N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 22952-32-5
5-chloro-2-methoxybenzenesulfonyl chloride

: 1186643-80-0
N-((1S)-1-{[(1S,4S)-5-(aminoacetyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl}-2,2-dimethylpropyl)-1H-indole-2-carboxamide

: 1186643-38-8
N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 774610-01-4
1,1-dimethylethyl(1S,4S)-5-(N-{[benzyloxy]carbonyl}glycyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 1186643-38-8
N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 2 h / 20 °C

5: ammonium formate / palladium on activated charcoal / ethanol / 2 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 1186643-38-8
N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 2 h / 20 °C

6: ammonium formate / palladium on activated charcoal / ethanol / 2 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;