1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

Base Information

Chemical Name:1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate
CAS No.:1391907-61-1
Molecular Formula:C₂₀H₂₀ClN₃O₅S
Molecular Weight:449.915
Hs Code.:

Synonyms:1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

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Chemical Property of 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

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Technology Process of 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

There total 6 articles about 1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1391908-12-5
1-(2-chlorophenyl)ethyl(5-(4-aminophenyl)-3-methylisoxazol-4-yl)carbamate

: 124-63-0
methanesulfonyl chloride

: 1391907-61-1
1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1391908-11-4
methyl 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylate

: 1391907-61-1
1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / 1,4-dioxane / 20 °C

1.2: pH < 6

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 125 °C / Sealed tube

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 91135-88-5
3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylic acid

: 1391907-61-1
1-(2-chlorophenyl)ethyl(3-methyl-5-(4-(methylsulfonamido)phenyl)isoxazol-4-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 125 °C / Sealed tube

2: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With diphenyl phosphoryl azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; toluene;