Technology Process of tert-butyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate
There total 5 articles about tert-butyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-1-(benzyloxy)-2-methylpentan-3-one;
With
dicyclohexylboron chloride; triethylamine;
In
diethyl ether; hexane;
at 0 ℃;
for 2h;
(4Z)-(6R)-6-tert-butoxycarbonylaminonon-4-enal;
In
diethyl ether; hexane;
at -78 - -20 ℃;
With
dihydrogen peroxide;
In
methanol; diethyl ether; water;
at 20 ℃;
for 3h;
DOI:10.1016/j.tet.2006.01.005
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 85 percent / DIBAL-H / toluene / 2 h / -78 °C
2.1: Et3N; dicyclohexylboron chloride / hexane; diethyl ether / 2 h / 0 °C
2.2: diethyl ether; hexane / -78 - -20 °C
2.3: 60 percent / hydrogen peroxide / H2O; diethyl ether; methanol / 3 h / 20 °C
With
dicyclohexylboron chloride; diisobutylaluminium hydride; triethylamine;
In
diethyl ether; hexane; toluene;
DOI:10.1016/j.tet.2006.01.005
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 100 percent / KOH / diethyl ether / 1 h / 0 °C
2.1: 78 percent / DIBAL-H / toluene / 2 h / -78 °C
3.1: sodium bistrimethylsilylamide / tetrahydrofuran / 1 h / 0 °C
3.2: 75 percent / tetrahydrofuran / 1 h / 0 °C
4.1: 85 percent / DIBAL-H / toluene / 2 h / -78 °C
5.1: Et3N; dicyclohexylboron chloride / hexane; diethyl ether / 2 h / 0 °C
5.2: diethyl ether; hexane / -78 - -20 °C
5.3: 60 percent / hydrogen peroxide / H2O; diethyl ether; methanol / 3 h / 20 °C
With
potassium hydroxide; dicyclohexylboron chloride; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; hexane; toluene;
3.2: Wittig reaction;
DOI:10.1016/j.tet.2006.01.005
