(2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

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Chemical Name:(2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid
CAS No.:1446652-89-6
Molecular Formula:C₃₂H₃₃N₃O₄
Molecular Weight:523.632
Hs Code.:

Synonyms:(2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

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Chemical Property of (2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

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Technology Process of (2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

There total 7 articles about (2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1446654-42-7
C₃₃H₃₅N₃O₄

: 1446652-89-6
(2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

Guidance literature:: C₃₃H₃₅N₃O₄; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; pH=3 - 4;

Reference yield:

: 1013033-83-4
tert-butyl 1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonane-7-carboxylate

: 1446652-89-6
(2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol / 3 h / 0 - 20 °C

2.1: triethylamine / methanol / 0.5 h / 20 °C

2.2: 20 °C

3.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

3.2: pH 3 - 4

With hydrogenchloride; lithium hydroxide monohydrate; triethylamine; In tetrahydrofuran; methanol; water;

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 1446652-89-6
(2S,4S)-1-(2,2-diphenylacetyl)-4-(1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonan-7-yl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 7 h / Reflux

2.1: thionyl chloride / 0.5 h / Reflux

2.2: 2 h / 0 - 20 °C

3.1: Jones reagent / acetone / 0.33 h / 0 - 20 °C

4.1: triethylamine / methanol / 0.5 h / 20 °C

4.2: 20 °C

5.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

5.2: pH 3 - 4

With thionyl chloride; lithium hydroxide monohydrate; Jones reagent; triethylamine; In tetrahydrofuran; methanol; water; acetone;