(R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

Base Information

Chemical Name:(R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine
CAS No.:1426414-41-6
Molecular Formula:C₂₀H₂₆BNO₃
Molecular Weight:339.242
Hs Code.:

Synonyms:(R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

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Chemical Property of (R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

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Technology Process of (R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

There total 3 articles about (R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 532391-31-4
2-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

: 133038-74-1
(S)-(-)-1-phenylethyl N,N-diisopropylcarbamate

: 1426414-41-6
(R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

Guidance literature:: (S)-(-)-1-phenylethyl N,N-diisopropylcarbamate; With sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 0.416667h;

2-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine; In diethyl ether; hexane; cyclohexane; at -78 ℃;

With magnesium bromide; In methanol; diethyl ether; hexane; cyclohexane; at -78 - 20 ℃; Reagent/catalyst;
DOI:10.1021/ol400289v

Reference yield:

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 1426414-41-6
(R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / diethyl ether / 16 h / 20 °C

2.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 0.42 h / -78 °C

2.2: -78 °C

2.3: -78 - 20 °C

With sec.-butyllithium; magnesium sulfate; In diethyl ether; hexane; cyclohexane;
DOI:10.1021/ol400289v

Reference yield:

: 163105-90-6
2-methoxypyridin-3-yl-boronic acid

: 1426414-41-6
(R)-2-methoxy-3-(1-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / diethyl ether / 16 h / 20 °C

2.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 0.42 h / -78 °C

2.2: -78 °C

2.3: -78 - 20 °C

With sec.-butyllithium; magnesium sulfate; In diethyl ether; hexane; cyclohexane;
DOI:10.1021/ol400289v