(S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole

Base Information

• Chemical Name: (S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole
• CAS No.: 854028-00-5
• Molecular Formula: C₂₂H₂₉NOSi
• Molecular Weight: 351.564

Synonyms:(S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole

Chemical Property of (S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole

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Technology Process of (S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole

There total 1 articles about (S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one (854027-99-9) → (S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole (854028-00-5)

Guidance literature:

With Cp₂YrHCl; In tetrahydrofuran; at -20 ℃; for 2.5h;

DOI:10.1021/ja063860+

Reference yield: 88.0%

(S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole (854028-00-5) + (Z)-3-(4-methoxy-benzyliminomethyleneamino)-but-2-enoic acid benzyl ester → 7-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester (854028-01-6)

Guidance literature:

In 1,2-dichloro-ethane; at 23 ℃;

DOI:10.1021/ja0519029

Reference yield: 86.0%

(S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole (854028-00-5) + (E)-3-(4-methoxy-benzyliminomethyleneamino)-but-2-enoic acid benzyl ester → 7-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester (854028-01-6)

Guidance literature:

In 1,2-dichloro-ethane; at 23 ℃; for 4.5h;

DOI:10.1021/ja0519029 DOI:10.1021/ja063860+

upstream raw materials:

(S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one

Downstream raw materials:

7-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester

7-(2-hydroxy-ethyl)-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydropyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester

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