(S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one

Base Information

• Chemical Name: (S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one
• CAS No.: 854027-99-9
• Molecular Formula: C₂₂H₂₉NO₂Si
• Molecular Weight: 367.563
• Mol file: 854027-99-9.mol

Synonyms:(S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one

Chemical Property of (S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one

There total 1 articles about (S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-5-(2-hydroxy-ethyl)-pyrrolidin-2-one (149427-84-9,808172-50-1) + tert-butylchlorodiphenylsilane (58479-61-1) → (S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one (854027-99-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1021/ja063860+

Reference yield: 66.0%

(S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one (854027-99-9) → (S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole (854028-00-5)

Guidance literature:

With Cp₂YrHCl; In tetrahydrofuran; at -20 ℃; for 2.5h;

DOI:10.1021/ja063860+

Reference yield:

(S)-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pyrrolidin-2-one (854027-99-9) → 7-(2-hydroxy-ethyl)-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydropyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester (854028-02-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Cp₂ZrHCl / tetrahydrofuran / 2.5 h / -20 °C

2: 88 percent / 1,2-dichloro-ethane / 23 °C

3: 99 percent / TBAF / tetrahydrofuran / 0.5 h

With Schwartz's reagent; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1021/ja0519029

upstream raw materials:

(S)-5-(2-hydroxy-ethyl)-pyrrolidin-2-one

tert-butylchlorodiphenylsilane

Downstream raw materials:

(S)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,4-dihydro-2H-pyrrole

7-(2-hydroxy-ethyl)-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydropyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester

7-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-(4-methoxy-benzylamino)-3-methyl-4a,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid benzyl ester