(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:110575-50-3
Molecular Formula:C₂₈H₄₃N₃O₆
Molecular Weight:517.666
Hs Code.:

Synonyms:(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 1 articles about (S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5241-58-7
L-Phenylalanine amide

: 110575-49-0
Boc-Asp(OMen)-OSu

: 110575-50-3
(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide;

Reference yield: 100.0%

: 110575-50-3
(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 5241-71-4
Asp-Phe-NH₂

Guidance literature:: With trifluorormethanesulfonic acid; methyl-phenyl-thioether; diphenyl sulfide; In trifluoroacetic acid; at 0 ℃; for 2h;

Reference yield:

: 110575-50-3
(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 110575-53-6,111004-09-2
H-Trp-Met-Asc-Phe-NH₂

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DCC, HONB; 2.) NMM, Et₃N, TFA / 1.) THF-DMF, 4 h; 2.) DMF, overnight

2: 1.) DCC, HOSu; 2.) NMM, Et₃N, TFA / 1.) THF, 5 h; 2.) DMF, overnight

3: 95 percent / trimethylphenylthiosilane / dimethylformamide / 0.25 h / 40 °C

4: 6 percent / 1 M TFMSA-thioanisole, EDT / trifluoroacetic acid / 2 h

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; ethylenediaminetetraacetic acid; trifluorormethanesulfonic acid; methyl-phenyl-thioether; phenylthiotrimethylsilane; triethylamine; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); trifluoroacetic acid; In N,N-dimethyl-formamide; trifluoroacetic acid;