5241-71-4

Basic information

• Product Name: H-ASP-PHE-NH2
• Synonyms: CAERULEIN 9-10;CHOLECYSTOKININ 32-33;L-ASPARTIC ACID-L-PHENYLALANINE AMIDE;H-ASP-PHE-NH2;GASTRIN 16-17;ALPHA-L-ASP-PHE-NH2;ASP-PHE AMIDE;Asp-Phe-NH2
• CAS NO: 5241-71-4
• Molecular Formula: C₁₃H₁₇N₃O₄
• Molecular Weight: 279.29
• Mol File: 5241-71-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 647 °C at 760 mmHg
• Flash Point: 345.1 °C
• Appearance: /
• Density: 1.326 g/cm³
• Storage Temp.: -15°C
• CAS DataBase Reference: H-ASP-PHE-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP-PHE-NH2(5241-71-4)
• EPA Substance Registry System: H-ASP-PHE-NH2(5241-71-4)

Safety Data

• Hazardous Substances Data: 5241-71-4(Hazardous Substances Data)

Usage

General Description

H-ASP-PHE-NH2, also known as aspartyl-phenylalanine amide, is a neuropeptide that acts as an agonist at neurotensin receptors. It is a synthetic compound derived from the amino acids aspartic acid and phenylalanine. As a neuropeptide, H-ASP-PHE-NH2 has been found to influence a variety of physiological functions including the regulation of the cardiovascular system, pain perception, and locomotor behavior. H-ASP-PHE-NH2 has also been studied for its potential therapeutic applications, particularly in the treatment of conditions such as schizophrenia, Parkinson's disease, and substance abuse. Overall, H-ASP-PHE-NH2 is a biologically active compound with potential implications for the understanding and treatment of various neurological and psychiatric disorders.

Upstream product

• 251991-33-0 α-aspartyl phenylalaninamide ammonium salt 
• 5241-58-7 L-Phenylalanine amide 
• 110575-50-3 (S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 86060-92-6 N-α-Fmoc-L-phenylalanine pentafluorophenyl ester 
• 797751-68-9 N^α-Fmoc-L-Asn-OPfp 
• 1947-39-3 N-benzyloxycarbonyl-aspartyl-phenylalanine amide 
• 5241-68-9 Z-Asp(OBzl)-Phe-NH₂ 
• 22839-47-0 L-Asp-L-Phe-OMe 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 

Downstream Products

• 160637-58-1 <<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide 
• 160557-10-8 <<4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide 
• 63229-05-0 L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate 
• 3918-98-7 Asp-Phe-OH 
• 109748-62-1 (S)-3-((R)-4-Benzyloxycarbonylamino-4-dipropylcarbamoyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid 
• 5920-14-9 N^α-tert-Butyloxycarbonyl-L-methionyl-L-aspartyl-L-phenylalanine amide 
• 130832-06-3 Boc-Cle-Asp-Phe-NH₂ 
• 134915-96-1 (S)-3-({2-[1-Amino-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carbonyl}-amino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid 
• 6464-61-5 H-Met-Asp-Phe-NH₂*HCl 
• 25576-01-6 (S)-3-((R)-4-Benzoylamino-4-dipropylcarbamoyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid 
• 5235-21-2 N-tert-butoxycarbonyl-L-tryptophyl->L-methionyl->L-α-aspartyl->L-phenylalanine amide 
• 134915-97-2 (S)-3-({2-[1-(2-Amino-acetylamino)-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carbonyl}-amino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid 

Relevant articles and documents

Method for preparing aspartylcyclohexyla laninamide

Disclosure is a method for preparing α-aspartyl-β-cyclohexylalaninamide, comprising carrying out a first step of amide formation of an α-aspartyl phenylamine ester of general formula (II) wherein: R is a C1-C4alkyl radical, and then

Protected-mode Synthesis of N-Linked Glycopeptides: Single-step Preparation of Building Blocks as Peracetyl Glycosylated NαFmoc Asparagine OPfp Esters

The preparation of Nα-(fluoren-9-ylmethoxycarbonyl)asparagine pentafluorophenyl esters (Nα-Fmoc-Asn-OPfp) glycosylated with per-O-acetylated β-D-glucose, N-acetyl-β-D-glucosamine, β-D-mannose, 4-O-β-D-glucopyranosyl-β-D-glucose (cellobiose), 4-O-β-D-galactopyranosyl-β-D-glucose (lactose) and 4-O-α-D-glucopyranosyl-β-D-glucose (maltose) is described.The per-O-acetylated glycosylamines were treated selectively with the key compound Nα-Fmoc-Asp(Cl)-OPfp 2, to give, in a single step, the glycosylated building blocks.The acid chloride 2 was prepared in a quantitative one-pot reaction from commercially available Nα-Fmoc-Asp(OBut)-OPfp 1.The acid stability of the N-glycosidic linkage was investigated.The building block 7, containing a maltose moiety, was used in the synthesis of a glycosylated D-Ala1 Peptide-T amide analogue 14.CD spectra were recorded in 85 percent TFE.All compounds were fully characterized by (1)H and (13)C NMR spectroscopy.

PAPAIN-CATALYZED FRAGMENT SYNTHESIS OF PROTECTED CHOLECYSTOKININ DERIVATIVES

Sodium salts of methyl esters of N-tert-butyloxycarbonyl-β-tert-butylaspartyl-O4-sulfotyrosine (II) or N-tert-butyloxycarbonyl-O4-sulfotyrosine (III) were condensed with amino components derived from peptide amides IVb-IVe and IVg (simulating the carboxy-terminal part of cholecystokinin) under catalysis with papain.Rates and yields of conversion of these peptides to the corresponding derivatives Ib-If were compared with the results reported previously for analogous papain-catalyzed fragment synthesis of the protected carboxy-terminal octapeptide of cholecystokinin Ia.In the condensation reactions with the individual amino components quantitative changes were observed in the ability of papain to catalyze the peptide bond synthesis which appeared as differences in the maximum yield (and the time required for achieving it) of the condensation reaction, monitored by HLPC.The observed differences are related not only with the distance of the amino acid substitution from the P'1 subsite in the given amino component but also with the side-chain structure of the substituting amino acid.