(R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

Base Information

Chemical Name:(R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione
CAS No.:1386998-19-1
Molecular Formula:C₁₆H₁₆ClF₃N₄OS
Molecular Weight:404.843
Hs Code.:

Synonyms:(R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

Suppliers and Price of (R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

There total 18 articles about (R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: decarborane

: 1266784-84-2
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

: 1357098-11-3
4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde

: 1386998-19-1
(R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

Guidance literature:: decarborane; (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride; 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde; In methanol; at 45 ℃; for 15h; Inert atmosphere;

With decarborane; In methanol; at 45 ℃; for 15h;

Reference yield: 60.0%

: 1266784-84-2
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

: 1357098-11-3
4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde

: 1386998-19-1
(R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

Guidance literature:: With nido-decaborane; at 45 ℃; for 15h;

Reference yield:

: 925179-02-8
1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid

: 1386998-19-1
(R)-5-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-5-methyl-morpholine-3-thione

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 2 h / 0 °C / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 50 °C

3.1: lithium hydroxide / water; tetrahydrofuran; methanol / 1 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -15 - 0 °C

5.2: 0.67 h / -15 - 20 °C

6.1: nido-decaborane / 15 h / 45 °C

With 4-methyl-morpholine; N-chloro-succinimide; lithium aluminium tetrahydride; nido-decaborane; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;