(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

Base Information

Chemical Name:(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride
CAS No.:1266784-84-2
Molecular Formula:C₁₁H₁₃FN₂OS
Molecular Weight:240.301
Hs Code.:

Synonyms:(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

Chemical Property:

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Technology Process of (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

There total 13 articles about (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1266784-91-1
(R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholine-3-thione

: 1266784-84-2
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 146328-85-0
5-bromo-2-fluoro-benzoic acid

: 1266784-84-2
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

Guidance literature:: Multi-step reaction with 12 steps

1: N,0-dimethylhydroxylamine; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 20 °C

2: methylmagnesium chloride / tetrahydrofuran / 0.33 h / 12 - 16 °C / Reflux

3: potassium cyanide / ethanol / 16 h / 120 °C / Autoclave

4: sodium hydroxide / water

5: thionyl chloride

6: lithium aluminium tetrahydride / tetrahydrofuran

7: acetonitrile

8: Reprosil Chiral NR / dichloromethane / Resolution of racemate

9: potassium tert-butylate

10: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 18 h / 105 °C / Inert atmosphere; Sealed vial

11: Lawessons reagent / 1,4-dioxane / 18 h / 80 °C / Sealed vial

12: hydrogenchloride / 1,4-dioxane / 20 °C

With Lawessons reagent; hydrogenchloride; potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; methylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; sodium t-butanolate; N,0-dimethylhydroxylamine; tert-butyl XPhos; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1266784-84-2
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: potassium cyanide / ethanol / 16 h / 120 °C / Autoclave

2: sodium hydroxide / water

3: thionyl chloride

4: lithium aluminium tetrahydride / tetrahydrofuran

5: acetonitrile

6: Reprosil Chiral NR / dichloromethane / Resolution of racemate

7: potassium tert-butylate

8: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 18 h / 105 °C / Inert atmosphere; Sealed vial

9: Lawessons reagent / 1,4-dioxane / 18 h / 80 °C / Sealed vial

10: hydrogenchloride / 1,4-dioxane / 20 °C

With Lawessons reagent; hydrogenchloride; potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydroxide; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;