3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

Base Information

Chemical Name:3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone
CAS No.:226990-76-7
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

Suppliers and Price of 3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

Chemical Property:

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Technology Process of 3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

There total 6 articles about 3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4112-65-6
5-hydroxy-2-methylisoindoline-1,3-dione

: 226990-76-7
3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / K₂CO₃ / acetone / 48 h / 70 °C

2: 74 percent / 3 h / 180 °C

3: 98 percent / H₂ / 5 percent Pd/C / ethanol / 1 h / Ambient temperature

4: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 8 h / Ambient temperature

5: 1.) Mg / 1.) THF, 50 deg C, 1 h, 2.) THF, RT, 8 h

With hydrogen; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1248/cpb.47.529

Reference yield:

: 610-35-5
4-hydroxyphthalic acid

: 226990-76-7
3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

Guidance literature:: Multi-step reaction with 6 steps

1: 59 percent / a) H₂O, 150 deg C, 1 h, b) H₂O, 190 deg C, 1 h

2: 78 percent / K₂CO₃ / acetone / 48 h / 70 °C

3: 74 percent / 3 h / 180 °C

4: 98 percent / H₂ / 5 percent Pd/C / ethanol / 1 h / Ambient temperature

5: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 8 h / Ambient temperature

6: 1.) Mg / 1.) THF, 50 deg C, 1 h, 2.) THF, RT, 8 h

With hydrogen; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1248/cpb.47.529

Reference yield:

: 131523-16-5
4-allyl-5-hydroxy-N-methylphthalimide

: 226990-76-7
3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-5-propyl-1-isoindolinone

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / H₂ / 5 percent Pd/C / ethanol / 1 h / Ambient temperature

2: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 8 h / Ambient temperature

3: 1.) Mg / 1.) THF, 50 deg C, 1 h, 2.) THF, RT, 8 h

With hydrogen; magnesium; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.47.529