4112-65-6

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-methyl-
• Synonyms: 5-hydroxy-N-methyl-1,3-dihydroisoindole-1,3-dione;5-hydroxy-N-methylphthalimide;4-hydroxy-N-methyl-phthalimide;5-hydroxy-2-methyl-isoindole-1,3-dione;5-hydroxy-2-methyl-isoindoline-1,3-dione;5-Hydroxy-2-methyl-isoindolin-1,3-dion
• CAS NO: 4112-65-6
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.159
• Mol File: 4112-65-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-methyl-(4112-65-6)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-methyl-(4112-65-6)

Safety Data

• Hazardous Substances Data: 4112-65-6(Hazardous Substances Data)

Usage

Derivative of isoindole

The compound is derived from isoindole, which is a type of organic compound that contains a fused benzene ring and a pyrrole ring.

White solid

The compound exists in a solid form and is white in color.

Used in pharmaceutical and chemical industries

The compound has potential applications in the synthesis of other organic compounds and can be used as a building block for the production of other chemical substances.

Potential biological activity

The compound may have some biological activity, which means it could potentially be used in the development of new drugs or pharmaceutical products.

Upstream product

• 2307-00-8 4-amino-N-methylphthalimide 
• 27550-59-0 4-hydroxyphthalic anhydride 
• 593-51-1 methylamine hydrochloride 
• 610-35-5 4-hydroxyphthalic acid 
• 74-89-5 methylamine 

Downstream Products

• 1242154-28-4 2-methylisoindole-1,3-dion-5-yl 3-[4-(tert-butoxycarbonyl)amino-2-methoxyphenyl]propionate 
• 1242154-29-5 2-methylisoindole-1,3-dion-5-yl 3-[4-(tert-butoxycarbonyl)amino-3-methoxyphenyl]propionate 
• 1242154-01-3 2-methylisoindole-1,3-dion-5-yl 2-(4-nitrophenyl) acetate 
• 1242154-13-7 2-methylisoindole-1,3-dion-5-yl 3-(4-methoxyphenyl) propionate 
• 1242154-03-5 2-methylisoindole-1,3-dion-5-yl (E)-3-(4-nitrophenyl) acrylate 
• 1242154-00-2 2-methylisoindole-1,3-dion-5-yl 2-(3-nitrophenyl) acetate 
• 1242154-04-6 2-methylisoindole-1,3-dion-5-yl 4-(4-nitrophenyl) butanoate 
• 1242154-02-4 2-methylisoindole-1,3-dion-5-yl (E)-3-(3-nitrophenyl) acrylate 
• 1242154-14-8 2-methylisoindole-1,3-dion-5-yl (E)-3-[4-(dimethyl-amino)phenyl]acrylate 
• 1242153-97-4 2-methylisoindole-1,3-dion-5-yl 2-aminobenzoate 
• 1242154-12-6 2-methylisoindole-1,3-dion-5-yl 3-phenylpropionate 
• 1242153-98-5 2-methylisoindole-1,3-dion-5-yl 3-nitrobenzoate 
• 1242153-99-6 2-methylisoindole-1,3-dion-5-yl 4-nitrobenzoate 
• 226990-78-9 7-allyl-3-hydroxy-2-methyl-6-methoxymethyloxy-3-phenylethyl-1-isoindolinone 

Relevant articles and documents

Naphthalimide/benzimide-based excited-state intramolecular proton transfer active luminogens: Aggregation-induced enhanced emission and potential for chemical modification

Fluorescent organic particles are important in a number of areas, including medical imaging; hence, the development of organic materials that exhibit aggregation-induced emissions is an important objective. To that end, we report the synthesis of naphthalimide- and benzimide-based 2-(2-hydroxyphenyl)benzothiazole (HBT) derivatives (HNIBT and HPIBT, respectively) that exhibit aggregation-induced emission enhancement (AIEE), in contrast to most naphthalimide- or benzimide-based derivatives that are prone to aggregation-induced quenching. Experimental studies like single-crystal X-ray diffraction analysis and theoretical calculations demonstrate that the ability to undergo excited-state intramolecular proton transfer is pivotal for AIEE. Further studies revealed that a terminal alkynyl chain at the N-imide site of HPIBT has little impact on the emission behavior of the resultant compound (HPIBT-yl). HPIBT-Pe, an amphiphilic molecule obtained through the click reaction of HPIBT-yl and a tetraethylene-glycol-derived azide, self-assembled to form highly photostable particles that have long-term fluorescence imaging potential in cellular environments.

Prostanoids and related compounds. VII. Synthesis and inhibitory activity of 1-isoindolinone derivatives possessing inhibitory activity against thromboxane A2 analog (U-46619)-induced vasoconstriction

We have synthesized a series of novel 1-isoindolinone derivatives, which inhibited the contraction of pig coronary artery induced by U-46619, a thromboxane A2 analog.

Synthesis and inhibitory activity of isoindolinone derivatives on thromboxane A2 analog (U-46619)-induced vasocontraction

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