N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

Base Information

Chemical Name:N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester
CAS No.:50515-47-4
Molecular Formula:C₄₇H₆₂N₆O₁₂
Molecular Weight:903.042
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

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Chemical Property of N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

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Technology Process of N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

There total 6 articles about N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 678159-24-5
N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

: 47794-30-9
N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester trifluoroacetic acid salt

: 50515-47-4
N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/jo035583k

Reference yield:

: 2483-49-0
tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester

: 50515-47-4
N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-1H-benzotriazole; Et₃N / dimethylformamide / 18 h / 20 °C

2: N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

3: 48 percent / HOBt; Et₃N / dimethylformamide / 20 h / 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035583k

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 50515-47-4
N-tert-butoxycarbonyl-L-alanyl-D-glutaminyl-(α-benzyl)-γ-N-ε-benzyloxycarbonyl-L-lysinyl-D-alanyl-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / Et₃N; EDCI; HOBt / CH₂Cl₂ / 15 h / 0 - 20 °C

2: CF₃CO₂H / 15 h / cooling

3: 48 percent / HOBt; Et₃N / dimethylformamide / 20 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035583k