N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

Base Information

Chemical Name:N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester
CAS No.:678159-24-5
Molecular Formula:C₂₆H₃₁N₃O₉
Molecular Weight:529.547
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

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Chemical Property of N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

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Technology Process of N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

There total 3 articles about N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 50515-48-5
(R)-5-(benzyloxy)-4-{(S)-2-[(tert-butoxycarbonyl)amino]propanamido}-5-oxopentanoic acid

: 678159-24-5
N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo035583k

Reference yield:

: 2483-49-0
tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester

: 678159-24-5
N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-1H-benzotriazole; Et₃N / dimethylformamide / 18 h / 20 °C

2: N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035583k

Reference yield:

: 79338-14-0
D-glutamic acid 1-benzyl ester

: 678159-24-5
N-tert-butoxycarbonyl-L-alanyl-D-glutamic acid α-benzyl-γ-p-nitrophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-1H-benzotriazole; Et₃N / dimethylformamide / 18 h / 20 °C

2: N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035583k