N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

Base Information

Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate
CAS No.:1195780-79-0
Molecular Formula:C₆H₆O₃S*C₃₀H₂₄FN₅O₄
Molecular Weight:695.728
Hs Code.:

N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

There total 10 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1195779-18-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

: 98-11-3
benzenesulfonic acid

: 1195780-79-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

Guidance literature:: In tetrahydrofuran; at 80 ℃;

Reference yield:

: 1175127-62-4
1-(4-fluorophenyl)-6-methyl-3-cyano-2-oxo-1,2-dihydropyridine

: 1195780-79-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / 20 h / 120 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

3: tetrahydrofuran / 80 °C

With sulfuric acid; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1195781-13-5
benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}carbamate

: 1195780-79-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide benzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: ISOPROPYLAMIDE / 1 h / 20 °C

2: water; barium(II) hydroxide / 1,2-dimethoxyethane / 36 h / 90 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

4: tetrahydrofuran / 80 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;