Technology Process of 1-(4-fluorophenyl)-6-methyl-3-cyano-2-oxo-1,2-dihydropyridine
There total 4 articles about 1-(4-fluorophenyl)-6-methyl-3-cyano-2-oxo-1,2-dihydropyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methoxy-3-buten-2-one; 2-cyano-N-[4-(fluoro)phenyl]acetamide;
With
1,4-diaza-bicyclo[2.2.2]octane;
In
2-(2-methoxyethoxy)ethyl alcohol;
at 120 ℃;
for 5h;
trans-4-methoxy-3-buten-2-one;
With
1,4-diaza-bicyclo[2.2.2]octane;
In
2-(2-methoxyethoxy)ethyl alcohol;
at 120 ℃;
for 1h;
- Guidance literature:
-
With
1,4-diaza-bicyclo[2.2.2]octane;
at 120 ℃;
for 14h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethylene glycol
With
benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide; diethylene glycol;
DOI:10.1021/op400317z
