4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

Base Information

Chemical Name:4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile
CAS No.:918660-40-9
Molecular Formula:C₂₅H₁₉Cl₂N₃O₅
Molecular Weight:512.349
Hs Code.:

Synonyms:4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

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Chemical Property of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

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Technology Process of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

There total 4 articles about 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 846023-51-6
4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-iodo-6-methoxy-3-quinolinecarbonitrile

: 2-(tributylstannyl)-5-(1,3-dioxolan-2-yl)-furan

: 918660-40-9
4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; for 4h; Heating;
DOI:10.1021/jm061031t

Reference yield:

: 846023-24-3
2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide

: 918660-40-9
4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: propan-2-ol / Heating

1.2: 85 percent / propan-2-ol / Heating

2.1: 29 percent / phosphorus oxychloride / acetonitrile; methanol / 24 h / Heating

3.1: 80 percent / dichlorobis(triphenylphosphine)palladium(II) / dioxane / 4 h / Heating

With trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; isopropyl alcohol; acetonitrile; 3.1: Stille coupling;
DOI:10.1021/jm061031t

Reference yield:

: 846023-38-9
(2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(3-iodo-4-methoxyphenyl)amino]-2-propenamide

: 918660-40-9
4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 29 percent / phosphorus oxychloride / acetonitrile; methanol / 24 h / Heating

2: 80 percent / dichlorobis(triphenylphosphine)palladium(II) / dioxane / 4 h / Heating

With trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; acetonitrile; 2: Stille coupling;
DOI:10.1021/jm061031t