846023-38-9

Upstream product

• 846023-24-3 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 
• 74587-12-5 3-iodo-4-methoxyaniline 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1334310-24-5 C₂₇H₂₇Cl₂N₇O₂ 
• 1334396-28-9 C₃₁H₃₃Cl₂N₇O₂ 
• 1334311-15-7 C₃₀H₃₁Cl₂N₇O₂ 
• 1334311-68-0 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-23-4 C₂₉H₃₁Cl₂N₇O₂ 
• 1334396-27-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334309-46-4 C₂₇H₂₈Cl₂N₈O₂ 
• 1334310-95-0 C₂₆H₂₅Cl₂N₇O₂ 
• 1334310-22-3 C₂₉H₂₉Cl₂N₇O₂ 
• 1334312-08-1 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-77-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334309-74-8 C₂₇H₂₇Cl₂N₇O₂ 
• 1334396-29-0 C₂₀H₁₃Cl₂N₃O₂ 
• 918660-40-9 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-6-methoxy-3-quinolinecarbonitrile 

Relevant academic research and scientific papers

Design, synthesis and pharmacokinetic evaluation of a novel series of triazole-based Src kinase inhibitors with anti-proliferative activity

Src has been recognized as an important therapeutic target for the treatment of cancer. A novel series of triazole-based Src inhibitors were synthesized and evaluated for their anti-proliferative activities in vitro against human lung cancer A549 cells wi

Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles

Compound 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5- methoxyphenyl)amino]-3-quinolinecarbonitrile, is a potent inhibitor of Src kinase activity. We previously reported that analogs of 1 with thiophene groups at C-7 retained the Src activity of

4 [(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-ALKOXY-7-ETHYNYL-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF ISCHEMIC INJURY

This invention relates to compounds of the formula (I): wherein: R is methyl or ethyl; R' and R" are independently alkyl of 1 to 3 carbon atoms, or R' and R", taken together with the nitrogen to which they are attached, can form a 5 or 6 membered saturate

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.