triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

Base Information

Chemical Name:triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate
CAS No.:1234572-96-3
Molecular Formula:C₃₂H₄₃I₄NO₇Si
Molecular Weight:1089.4
Hs Code.:

Synonyms:triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

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Chemical Property of triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

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Technology Process of triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

There total 3 articles about triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1234572-94-1
triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate

: 3132-64-7,82584-73-4
1,2-Epoxy-3-bromopropane

: 1234572-95-2
oxiran-2-ylmethyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

: 1234572-96-3
triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

Guidance literature:: triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

1,2-Epoxy-3-bromopropane; In tetrahydrofuran; at 65 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.04.011

Reference yield:

: 51-48-9,24486-40-6
L-thyroxine

: 1234572-95-2
oxiran-2-ylmethyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

: 1234572-96-3
triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 12 h / 20 - 65 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1234572-95-2
oxiran-2-ylmethyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

: 1234572-96-3
triisopropylsilyl 2-(tert-butoxycarbonylamino)-3-(4-(3,5-diiodo-4-(oxiran-2-ylmethoxy)phenoxy)-3,5-diiodophenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 12 h / 20 - 65 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;