diethyl benzyl(oct-1-yn-1-yl)phosphoramidate

Base Information

• Chemical Name: diethyl benzyl(oct-1-yn-1-yl)phosphoramidate
• CAS No.: 1332480-36-0
• Molecular Formula: C₁₉H₃₀NO₃P
• Molecular Weight: 351.426
• Mol file: 1332480-36-0.mol

Synonyms:diethyl benzyl(oct-1-yn-1-yl)phosphoramidate

Chemical Property of diethyl benzyl(oct-1-yn-1-yl)phosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl benzyl(oct-1-yn-1-yl)phosphoramidate

There total 2 articles about diethyl benzyl(oct-1-yn-1-yl)phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-bromo-1-octyne (38761-67-0) + diethyl N-benzylphosphoramidate (53640-96-3) → diethyl benzyl(oct-1-yn-1-yl)phosphoramidate (1332480-36-0)

Guidance literature:

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; at 95 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol201947b

Reference yield:

benzylamine (100-46-9) → diethyl benzyl(oct-1-yn-1-yl)phosphoramidate (1332480-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iodoform / diethyl ether / Inert atmosphere

2: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 24 h / 95 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; iodoform; In diethyl ether; toluene;

DOI:10.15227/orgsyn.092.0156

Reference yield: 88.0%

diethyl benzyl(oct-1-yn-1-yl)phosphoramidate (1332480-36-0) + 2-diazo-1-(2,4-dimethylphenyl)ethan-1-one → diethyl benzyl(3-hexyl-4-hydroxy-6,8-dimethylnaphthalen-2-yl)phosphoramidate

Guidance literature:

diethyl benzyl(oct-1-yn-1-yl)phosphoramidate; 2-diazo-1-(2,4-dimethylphenyl)ethan-1-one; In dichloromethane; Inert atmosphere; Flow reactor;

In toluene; for 5h; Reflux; Inert atmosphere; Flow reactor;

DOI:10.15227/orgsyn.93.0127

upstream raw materials:

1-bromo-1-octyne

diethyl N-benzylphosphoramidate

benzylamine

Downstream raw materials:

2-hexyl-3-(N-benzyl-N-(diethoxyphosphoryl))-2-cyclobuten-1-one

Refernces

• 1、 Dekorver, Kyle A.,Walton, Mary C.,North, Troy D.,Hsung, Richard P.. "Introducing a new class of N-phosphoryl ynamides via Cu(I)-catalyzed amidations of alkynyl bromides". supporting information; experimental part. p. 4862 - 4865. Retrieved 2011/11/29.