6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde

Base Information

• Chemical Name: 6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde
• CAS No.: 219781-98-3
• Molecular Formula: C₉H₇F₃O₆S
• Molecular Weight: 300.212
• Mol file: 219781-98-3.mol

Synonyms:6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde

Chemical Property of 6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde

There total 2 articles about 6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-[(trifluoromethanesulfonyl)oxy]-7-methoxy-2-methylbenzo[b]furan (219782-00-0) → 6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde (219781-98-3)

Guidance literature:

4-[(trifluoromethanesulfonyl)oxy]-7-methoxy-2-methylbenzo[b]furan; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With 2,3-dimercapto-succinic acid; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In ethanol; for 1h; Heating;

DOI:10.1055/s-2002-19799

Reference yield:

4-hydroxy-7-methoxy-2-methylbenzofuran (145103-54-4) → 6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde (219781-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 99 percent / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

2.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

2.2: DMS / CH₂Cl₂ / 1 h / 20 °C

2.3: 45 percent / aq. HCl / ethanol / 1 h / Heating

With ozone; triethylamine; In dichloromethane;

DOI:10.1055/s-2002-19799

Reference yield: 87.0%

6-[(trifluoromethanesulfonyl)oxy]-2-hydroxy-3-methoxybenzaldehyde (219781-98-3) + methyl iodide (74-88-4) → 6-[(trifluoromethanesulfonyl)oxy]-2,3-dimethoxybenzaldehyde (423171-77-1)

Guidance literature:

With potassium carbonate;

DOI:10.3987/COM-98-8284

upstream raw materials:

4-[(trifluoromethanesulfonyl)oxy]-7-methoxy-2-methylbenzo[b]furan

4-hydroxy-7-methoxy-2-methylbenzofuran

Downstream raw materials:

6-[(trifluoromethanesulfonyl)oxy]-2,3-dimethoxybenzaldehyde

oxychelerythrine

6-[(trifluoromethanesulfonyl)oxy]-2,3-dimethoxybenzoic acid

6-[(trifluoromethanesulfonyl)oxy]-2,3-dimethoxy-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide