N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide

Base Information

• Chemical Name: N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide
• CAS No.: 1592942-90-9
• Molecular Formula: C₂₂H₂₄N₄O₃
• Molecular Weight: 392.458

Synonyms:N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide

Chemical Property of N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide

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Technology Process of N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide

There total 3 articles about N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(2-azidophenyl)-N-tert-butyl-2-(3-(3-methoxyphenyl)prop-2-ynyloxy)acetamide (1592942-63-6) → N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide (1592942-90-9)

Guidance literature:

In toluene; at 100 ℃; for 2h; Microwave irradiation;

DOI:10.1021/ol500813p

Reference yield:

2-azidobenzaldehyde (16714-25-3) → N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide (1592942-90-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 48 h / 20 °C / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydroxide; water / dichloromethane / 20 °C / Inert atmosphere

3: toluene / 2 h / 100 °C / Microwave irradiation

With tetrabutylammomium bromide; water; sodium hydroxide; In dichloromethane; toluene; 1: |Passerini Condensation;

DOI:10.1021/ol500813p

Reference yield:

1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl acetate (1193490-24-2) → N-tert-butyl-3-(3-methoxyphenyl)-4,6-dihydrobenzo[e][1,2,3]triazolo[5,1-c][1,4]oxazepine-6-carboxamide (1592942-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide; water / dichloromethane / 20 °C / Inert atmosphere

2: toluene / 2 h / 100 °C / Microwave irradiation

With tetrabutylammomium bromide; water; sodium hydroxide; In dichloromethane; toluene;

DOI:10.1021/ol500813p

upstream raw materials:

2-azidobenzaldehyde

1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl acetate

2-(2-azidophenyl)-N-tert-butyl-2-(3-(3-methoxyphenyl)prop-2-ynyloxy)acetamide

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