N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide

Base Information

• Chemical Name: N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide
• CAS No.: 118743-82-1
• Molecular Formula: C₂₀H₂₄N₂O₃
• Molecular Weight: 340.422
• Mol file: 118743-82-1.mol

Synonyms:N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide

Chemical Property of N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide

There total 3 articles about N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(R)-(+)-α-methylbenzylhydroxylamine oxalate (118743-81-0) + 4-[(benzyloxycarbonyl)amino]butyric aldehyde (69037-98-5) → N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide (118743-82-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

benzyl 4-hydroxybutylcarbamate (17996-13-3) → N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide (118743-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) DMSO, oxalyl chloride, 2.) triethylamine / CH₂Cl₂ / -60 °C

2: triethylamine / CH₂Cl₂ / 5 h / 20 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;

DOI:10.1039/c39880000654

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide (118743-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 5 M NaOH / 0 °C

2: 1.) DMSO, oxalyl chloride, 2.) triethylamine / CH₂Cl₂ / -60 °C

3: triethylamine / CH₂Cl₂ / 5 h / 20 °C

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;

DOI:10.1039/c39880000654

upstream raw materials:

(R)-(+)-α-methylbenzylhydroxylamine oxalate

4-[(benzyloxycarbonyl)amino]butyric aldehyde

benzyl 4-hydroxybutylcarbamate

benzyl chloroformate

Downstream raw materials:

5-Acetoxy-3(R)-(4-benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidine

5-Acetoxy-3(S)-(4-benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidine

3(R)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-ol

3(S)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-ol