Palonidipine hydrochloride

Base Information

Chemical Name:Palonidipine hydrochloride
CAS No.:96515-74-1
Molecular Formula:C₂₉H₃₄FN₃O₆*ClH
Molecular Weight:576.065
Hs Code.:
UNII:9D73PQ95UJ
DSSTox Substance ID:DTXSID5021099
Mol file:96515-74-1.mol

Synonyms:3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl methyl-2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride;TC 81;TC-81

Suppliers and Price of Palonidipine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
PALONIDIPINE HYDROCHLORIDE 95.00%
5MG
$ 502.14

Total 1 raw suppliers

Chemical Property of Palonidipine hydrochloride

Chemical Property:

Vapor Pressure:2.96E-15mmHg at 25°C
Boiling Point:619.1°C at 760 mmHg
Flash Point:328.2°C
PSA：113.69000
LogP:6.49710
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:575.2198417
Heavy Atom Count:40
Complexity:982

Purity/Quality:

99% ^*data from raw suppliers

PALONIDIPINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCC(C)(C)CN(C)CC2=CC=CC=C2)C3=C(C=CC(=C3)[N+](=O)[O-])F)C(=O)OC.Cl

Technology Process of Palonidipine hydrochloride

There total 4 articles about Palonidipine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13426-94-3
N-methylbenzylamine hydrochloride

: 96515-74-1
Palonidipine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) NaBH₄ / 1.) 2-propanol, reflux, 6 h, 2.) MeOH, RT, 3 h

2: 96 percent / benzene / 1.5 h

3: 93 percent / NH₃ gas / Ambient temperature

4: 1.) HCl gas, 2.) Et₃N / 1.) toluene, RT, overnight, 2.) 2-propanol, reflux, 3 h

With hydrogenchloride; sodium tetrahydroborate; ammonia; triethylamine; In benzene;
DOI:10.1248/cpb.40.2049

Reference yield:

: 96516-26-6
3-(N-benzyl-N-methylamino)-2,2-dimethylpropanol

: 96515-74-1
Palonidipine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / benzene / 1.5 h

2: 93 percent / NH₃ gas / Ambient temperature

3: 1.) HCl gas, 2.) Et₃N / 1.) toluene, RT, overnight, 2.) 2-propanol, reflux, 3 h

With hydrogenchloride; ammonia; triethylamine; In benzene;
DOI:10.1248/cpb.40.2049

Reference yield:

: 96516-25-5
3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate

: 96515-74-1
Palonidipine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NH₃ gas / Ambient temperature

2: 1.) HCl gas, 2.) Et₃N / 1.) toluene, RT, overnight, 2.) 2-propanol, reflux, 3 h

With hydrogenchloride; ammonia; triethylamine;
DOI:10.1248/cpb.40.2049