2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Base Information

Chemical Name:2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone
CAS No.:909720-26-9
Molecular Formula:C₂₄H₂₄N₄O₄
Molecular Weight:432.479
Hs Code.:

Synonyms:2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Suppliers and Price of 2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

There total 5 articles about 2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80866-47-3
methyl 4-methylpent-2-ynoate

: 909720-25-8
2-benzyl-6-(6-methoxypyridine-3-yl)-2H-pyridazine-3-one

: 909720-26-9
2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Guidance literature:: methyl 4-methylpent-2-ynoate; 2-benzyl-6-(6-methoxypyridine-3-yl)-2H-pyridazine-3-one; With mesitylenesulfonylhydroxylamine; In dichloromethane; at -15 - 20 ℃; for 1h;

methyl 4-methylpent-2-ynoate; With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 909720-26-9
2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 1 h / -78 - 20 °C

1.3: pH 6

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 18 h / Heating / reflux

3.1: mesitylenesulfonylhydroxylamine / dichloromethane / 1 h / -15 - 20 °C

3.2: 18 h / 0 - 20 °C

With n-butyllithium; mesitylenesulfonylhydroxylamine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

: 100-39-0
benzyl bromide

: 909720-26-9
2-benzyl-6-(7-methoxy-3-methoxycarbonyl-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 1,2-dimethoxyethane / 0.25 h / 20 °C

1.2: 3.5 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 18 h / Heating / reflux

3.1: mesitylenesulfonylhydroxylamine / dichloromethane / 1 h / -15 - 20 °C

3.2: 18 h / 0 - 20 °C

With mesitylenesulfonylhydroxylamine; sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;