2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

Base Information

Chemical Name:2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl
CAS No.:396725-69-2
Molecular Formula:C₃₂H₃₁NO₄S
Molecular Weight:525.668
Hs Code.:

Synonyms:2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

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Chemical Property of 2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

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Technology Process of 2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

There total 6 articles about 2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4'-{[1-(4-tert-Butoxycarbonylsulfanyl-phenyl)-meth-(E)-ylidene]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester

: 396725-69-2
2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

Guidance literature:: With sodium tetrahydroborate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm0103099

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 396725-69-2
2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / DMAP; Et₃N / tetrahydrofuran / 20 °C

2: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

3: 516 mg / NaBH₄ / tetrahydrofuran / 1 h / 0 °C

4: 90 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

5: AcOH / CH₂Cl₂ / 1 h / 20 °C

6: 69 mg / NaBH₄ / CH₂Cl₂ / 2 h / 20 °C

With dmap; sodium tetrahydroborate; oxalyl dichloride; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 4: Swern oxidation;
DOI:10.1021/jm0103099

Reference yield:

: 1074-36-8
4-mercaptobenzoic acid

: 396725-69-2
2-phenyl-4-(4-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / DMAP; Et₃N / tetrahydrofuran / 20 °C

2: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

3: 516 mg / NaBH₄ / tetrahydrofuran / 1 h / 0 °C

4: 90 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

5: AcOH / CH₂Cl₂ / 1 h / 20 °C

6: 69 mg / NaBH₄ / CH₂Cl₂ / 2 h / 20 °C

With dmap; sodium tetrahydroborate; oxalyl dichloride; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 4: Swern oxidation;
DOI:10.1021/jm0103099