N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Base Information

Chemical Name:N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide
CAS No.:171010-30-3
Molecular Formula:C₂₁H₂₉NO₈S
Molecular Weight:455.529
Hs Code.:

Synonyms:N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Suppliers and Price of N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

There total 6 articles about N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 124-63-0
methanesulfonyl chloride

: 171010-29-0
N-(Bis(ethoxycarbonyl)methyl)-3-hydroxy-7-phenyl-6-heptenamide

: 171010-30-3
N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/jo00124a035

Reference yield:

: 21087-29-6
trans-3-phenylprop-2-enyl chloride

: 171010-30-3
N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaH, n-BuLi

2: NaBH₄ / methanol / 1.5 h / -60 - 10 °C

3: 1 M NaOH / tetrahydrofuran / 1 h / 25 °C

4: 1.) DCC, N-hydroxysuccinimide, 2.) Et₃N / 1.) THF, 25 deg C, 16 h, 2.) DMSO, 25 deg C, 16 h

5: 81 percent / Et₃N / tetrahydrofuran / 2 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; n-butyllithium; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jo00124a035

Reference yield:

: 13433-00-6
diethyl aminomalonate hydrochloride

: 171010-30-3
N-(Bis(ethoxycarbonyl)methyl)-3-(methylsulfonyloxy)-7-phenyl-6-heptenamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DCC, N-hydroxysuccinimide, 2.) Et₃N / 1.) THF, 25 deg C, 16 h, 2.) DMSO, 25 deg C, 16 h

2: 81 percent / Et₃N / tetrahydrofuran / 2 h / 0 °C

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jo00124a035