N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

Base Information

Chemical Name:N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide
CAS No.:433957-83-6
Molecular Formula:C₂₃H₁₈N₄O₄
Molecular Weight:414.42
Hs Code.:

Synonyms:N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

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Chemical Property of N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

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Technology Process of N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

There total 7 articles about N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 433958-58-8
N-{3-[2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

: 433957-83-6
N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0960-894X(02)01046-6

Reference yield:

: 82977-45-5
tetrahydro-5-oxofuran-2-carboxylic acid chloride

: n-tetrabutylammonium fluoride

: 433958-46-4
2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile

: 433958-58-8
N-{3-[2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

: 433957-83-6
N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; acetonitrile;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 433957-83-6
N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 18 percent / ammonium acetate / dioxane / Heating

2: 87 percent / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C

3: 77 percent / pyridine / acetonitrile / 0 - 20 °C

4: 93 percent / n-Bu₄NF / tetrahydrofuran / 0 °C

With pyridine; ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; acetonitrile;
DOI:10.1016/S0960-894X(02)01046-6