2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile

Base Information

• Chemical Name: 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile
• CAS No.: 433958-46-4
• Molecular Formula: C₂₄H₂₈N₄OSi
• Molecular Weight: 416.598

Synonyms:2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile

Chemical Property of 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile

There total 5 articles about 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile (433958-46-4)

Guidance literature:

Reference yield: 87.0%

2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}-phenyl)-4-(3-nitrophenyl)pyridine-3-carbonitrile (433958-47-5) → 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile (433958-46-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

DOI:10.1016/S0960-894X(02)01046-6

Reference yield: 18.0%

3-nitro-benzaldehyde (99-61-6) + 1-(2-(((1,1-dimethylethyl)dimethylsilyl)oxy)phenyl)ethanone (120820-40-8) + malononitrile (109-77-3) → 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile (433958-46-4) + 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}-phenyl)-4-(3-nitrophenyl)pyridine-3-carbonitrile (433958-47-5)

Guidance literature:

With ammonium acetate; In toluene;

upstream raw materials:

2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}-phenyl)-4-(3-nitrophenyl)pyridine-3-carbonitrile

3-nitro-benzaldehyde

1-(2-(((1,1-dimethylethyl)dimethylsilyl)oxy)phenyl)ethanone

malononitrile

Downstream raw materials:

N-{3-[2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-pyridinyl]phenyl}-3-(1-piperidinyl)propanamide

N-{3-[2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide

2-amino-4-(3-aminophenyl)-6-(2-hydroxyphenyl)nicotinonitrile

N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-3-(1-piperidinyl)propanamide hydrochloride

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